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Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles
Michael Kahn (editor) and Keane Lai (editor)
2022
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Dysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers which discuss the role of Wnt signaling and associated targets in cancer metabolism, tumor immune response, and tumor microenvironment. Papers discussing a range of Wnt-mediated cancers, including those of the colon, liver, pancreas, synovium, bladder, etc., are included.
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Keywords
- AML
- Angiogenesis
- anti-angiogenic therapy
- APC
- astrocytic brain tumors
- Cancer
- cancer stem cells
- cancer therapy
- CBP
- Cell Adhesion
- colitis
- colon cancer
- colorectal
- colorectal cancer
- DKKs
- Drug Discovery
- Drug Target
- EMT
- Fibrosis
- fungi secondary metabolite derivative
- Gastrointestinal cancers
- GSK3β
- HBV
- hepatitis B virus
- IBD
- immune checkpoint inhibitor
- Immunotherapy
- immunotherapy resistance
- invasion and metastasis
- just-right signaling
- L1
- LGR5
- liver cancer
- medicine
- microenvironment
- molecular targeting
- molecular therapeutics
- Musashi
- MYC
- NCB-0846
- NF-κB
- Notch signaling
- Other branches of medicine
- P300
- Pancreatic Cancer
- Pancreatic Stellate Cells
- Pancreatitis
- Pharmacology
- porcupine
- precision medicine
- R-spondin
- RNA-binding proteins
- serrated
- signaling
- synovial sarcoma
- TCF/LEF
- therapeutic targeting of Wnt signaling
- TNIK
- tumor immunology
- tumor metabolism
- urothelial cancer
- Vitamin D
- Wnt
- Wnt signaling
- Wnt target genes
- Wnt/beta-catenin signaling
- β-catenin
- β-catenin mutations
- β-catenin paradox
Links
DOI: 10.3390/books978-3-0365-3518-0Editions