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Mitochondrial Transport Proteins
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Mitochondrial transporters are membrane-inserted proteins which provide a link between metabolic reactions occurring within the mitochondrial matrix and outside the organelles by catalyzing the translocation of numerous solutes across the mitochondrial membrane. They include the mitochondrial carrier family members, the proteins involved in pyruvate transport, ABC transporters and channels, and are, therefore, essential for many biological processes and cell homeostasis. Identification and functional studies of many mitochondrial transporters have been performed over the years using both in vitro and in vivo systems. The few recently solved structures of these transporters have paved the way for further investigations. Furthermore, alterations in their function are responsible for several diseases.
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Keywords
- 22.q11.2
- ABC transporter
- adult-onset type II citrullinemia (CTLN2)
- Amino acid
- animal model
- Apoptosis
- aquaporin
- argininosuccinate synthetase (ASS)
- aspartate/glutamate carrier (AGC)
- ATP
- ATP synthase
- ATP synthase oligomers mitochondrial cristae morphology
- ATP-dependent potassium channel
- aversion to carbohydrates
- Bioenergetics
- biological function
- Biology, Life Sciences
- Ca2+ signaling
- Calcium
- Cancer
- carnitine
- carnitine acyl-carnitine carrier
- carnitine acyl-carnitine translocase
- Carrier
- CIC
- citrate
- citrin
- cofactor
- CTP
- cyclophilin D
- cyclosporin A
- diabetes
- Disease
- Diseases
- Electrophysiology
- error of metabolism
- food taste
- function
- gene promoter
- glucolipotoxicity
- glucose-induced expression
- glucose-stimulated insulin secretion
- glucotoxicity
- hypoxia
- Inflammation
- inner mitochondrial membrane
- ion
- Ion Channels
- ischemia/reperfusion
- isoforms
- LETM
- Lifespan
- lipotoxicity
- Mathematics & science
- MCF
- MCU
- membrane subunits of ATP synthase
- membrane transport
- Metabolic disorders
- Metabolism
- metabolite transport
- Mitochondria
- mitochondrial biogenesis
- mitochondrial Ca2+ uniporter
- mitochondrial Ca2+-induced permeability transition pore
- mitochondrial calcium transport
- mitochondrial calcium uniporter complex
- mitochondrial carrier
- mitochondrial carrier disease
- mitochondrial carrier family
- mitochondrial carriers
- mitochondrial disease
- mitochondrial metabolism
- mitochondrial permeability transition
- mitochondrial pyruvate carrier
- mitochondrial transport
- mitochondrial transporter
- MPC
- Mutation
- NAD
- NAD+ transporters
- NAFLD/NASH
- necrosis
- neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)
- neurodegeneration
- organic acid
- oxidative post-translational modification
- pancreatic islets
- Peroxisomes
- plant development
- plant metabolism
- Post-translational modification
- potassium channel openers
- potassium channels
- protein targeting
- protein translocation
- protein–protein interaction
- pyruvate metabolism
- Reference, information & interdisciplinary subjects
- Research & information: general
- resistance to hypoxia
- ROS
- sequence analysis
- sideroflexin
- skeletal muscle mitochondria
- SLC transporters
- SLC25
- SLC25.
- SLC25A1
- SLC25A20
- SLC25A51
- SLC54
- SLC55
- SLC56
- solute carrier family 25
- substrate specificity
- TIM chaperones
- TIM22
- TOM
- transport mechanism
- USMG5/DAPIT
- VDAC1
- virus
- vitamin
- Voltage-Dependent Anion selective Channel
- Yeast
- β-cell
Links
DOI: 10.3390/books978-3-0365-3409-1Editions