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A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus
Daniele Lana
2015
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Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the pathophysiological processes at the base of the cognitive impairments in different experimental models of neurodegeneration: in particular normal brain aging, neuroinfiammation and chronic cerebral hypoperfusion. These mechanisms are studied focusing on the morpho-functional alterations in the neuron-astrocytemicroglia triad.
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Keywords
- Clinical & internal medicine
- Medical imaging
- medicine
- Neurology & clinical neurophysiology
- Neurosurgery
- Other branches of medicine
- Surgery
- thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
- thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging
- thema EDItEUR::M Medicine and Nursing::MN Surgery::MNN Neurosurgery
Links
DOI: 10.36253/978-88-6655-941-2Editions