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Phospholipases: From Structure to Biological Function
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Phospholipases are a ubiquitous group of enzymes that hydrolyze ester bonds within membrane phospholipids. These enzymes serve multiple biological functions that go far beyond a mere membrane remodeling role in cellular homeostasis; they also play key functions in nutrient digestion and the regulated formation of bioactive lipids involved in cell signaling. It is to the latter function, critical to life, that this book is primarily concerned with. All the chapters are written by renowned experts in the area, and provide forefront information on the role phospholipases in a number of physiological and pathophysiological settings.
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Keywords
- acidic sphingomyelinase
- adipokines
- adrenic acid
- alcoholic and nonalcoholic steatohepatitis
- anti-inflammatory
- arachidonic acid
- Atherosclerosis
- autoinflammatory
- autotaxin
- Biology, Life Sciences
- ceramide
- choline and methionine deficiency
- chronic non-bacterial osteomyelitis
- chronic recurrent multifocal osteomyelitis
- cPLA2α
- crotoxin
- Cytokines
- diacylglycerol
- diet-induced obesity
- EP receptors
- fatty acid
- fatty liver
- G protein-coupled receptor
- Glioblastoma
- glucose tolerance
- Group V phospholipase A2
- group VIA phospholipase A2
- hepatocellular carcinoma
- Inflammasome
- Inflammation
- inflammatory response
- inhibitor
- Insulin Resistance
- insulin secretion
- knockout mouse
- lipid mediator
- lipid mediators
- lipid signaling
- lipidomics
- Lipids
- lipin
- LIPIN2
- lipins
- LPIN2
- lung impairment
- lysophosphatidate
- lysophospholipid
- macrophage
- Macrophages
- majeed syndrome
- Mass Spectrometry
- Mathematics & science
- membrane
- metabolic stability
- metastasis
- monocytes/macrophages
- morbidly obesity
- n/a
- neuromuscular blocker
- neutral sphingomyelinase
- osteoclast
- oxoesters
- pancreatic islets
- PAP-2
- phosphatidic acid
- phospholipase A2
- Phospholipases
- phospholipid
- phospholipid remodeling
- PLA2G6
- preadipocytes
- proliferation
- prostaglandins
- psoriasis
- Reference, information & interdisciplinary subjects
- Research & information: general
- signaling
- snake venom
- sphingolipid
- sphingomyelin
- sphingomyelinase
- sphingosine-1-phosphate
- T cells
- α-methylation
- β-cells
Links
DOI: 10.3390/books978-3-0365-4063-4Editions