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Mitochondria-targeted drug delivery
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Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers.
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Keywords
- alkylphospholipid analog
- anticancer peptide (ACP)
- anticancer peptides
- antimicrobial peptide (AMP)
- antimicrobial peptides
- antitumor agents
- ATP production
- Biology, Life Sciences
- blood–brain barrier
- cancer drug resistance
- Cancer Metabolism
- Cardiovascular Disease
- Central nervous system
- cholesterol
- cytotoxic effect
- differentiation
- diphenyleneiodonium
- Drug delivery
- edelfosine
- endothelial
- fluorescence lifetime imaging
- Gene Therapy
- heteroplasmy
- host defense peptides
- hypoxia
- Inflammation
- lipid raft
- LPS
- malate-aspartate shuttle
- Mathematics & science
- medicinal chemistry
- Melanoma
- metabolic drug
- Metabolism
- Mitochondria
- mitochondria dysfunctions
- mitochondria-targeted antioxidants
- mitochondrial carrier
- mitochondrial disease
- mitochondrial disorders
- mitochondrial DNA
- mitochondrial gene delivery
- mitochondrial oncometabolites
- mitochondrial permeability transition pore
- mitochondrial ROS
- n/a
- NADPH-oxidase
- nanocarriers
- Neuron
- Oxidative Stress
- oxoglutarate carrier
- pharmacological therapy
- plumbagin
- precision medicine
- prediction
- proliferation
- random forest
- Reactive Oxygen Species
- Reference, information & interdisciplinary subjects
- Research & information: general
- retinal ischemia
- tunneling nanotubules
Links
DOI: 10.3390/books978-3-0365-4040-5Editions