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Theme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th Birthday: Natural Products in Modern Drug Discovery
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Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.
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Keywords
- ampullosporin
- Angiogenesis
- anti-tumor peptides
- antibody engineering
- anticancer
- anticancer activity
- antifungal
- antiproliferative
- Apoptosis
- apoptosis resistance
- ATG 4B
- biorthogonal chemistry
- bispecific antibody
- botanical agents
- Breast cancer
- butein
- cancer stem cells
- cancer treatment
- caspase-3
- Chemistry
- click chemistry
- co-culture
- Coronavirus
- Cosmospora sp.
- COX inhibitory
- Cytotoxic
- cytotoxic activity
- DARTS
- Decachaeta incompta
- demissidine
- docking
- drug resistance
- ECD-TDDFT
- electron paramagnetic resonance (EPR) spectroscopy
- Flavonoids
- frondoside-A
- fusidic acid
- glutamic acid methyl ester
- hepatocellular carcinoma
- in vitro model
- incomptine A
- Invasion
- iTRAQ
- kaempferol
- lung cancer
- Magnaporthe oryzae
- marine fungi
- Mathematics & science
- medicinal herbs
- Melanoma
- MERS-CoV
- metabolomics
- metastasis
- molecular docking
- molecular networking
- multi-component reaction
- n/a
- Natural Products
- ophiobolin A
- Organic Chemistry
- PCD
- peptaibols
- Phytochemicals
- phytopathogen
- polygodial
- Pregnancy
- proliferation
- RCE-4
- Reference, information & interdisciplinary subjects
- Research & information: general
- ROS production
- SARS-CoV
- SARS-CoV-2
- Sepedonium ampullosporum
- sesquiterpene lactone
- solanidane alkaloids
- solanidine
- solid-phase peptide synthesis
- soudanone
- Sparticola junci
- src
- STAT3
- stemness
- steroidal alkaloids
- structure elucidation
- Target identification
- TEMPO-conjugate
- the Bcl-2–Beclin 1 complex
- Trypsiligase
- tumor growth
- tumor heterogeneity
- tumor microenvironment (TME)
- viability
- violacein
- Wittig reaction
Links
DOI: 10.3390/books978-3-0365-4743-5Editions