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Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes
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The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications.
This book is included in DOAB.
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Keywords
- 3-methyladenine
- 3D culture
- adipose tissue-derived stem cells (ASCs)
- adipose-derived stem cell
- AKB-6548
- Angiogenesis
- Astrocytes
- Autophagy
- axon growth
- CD206
- cell therapy
- Chemotaxis
- combination therapy
- engineered cardiac patches
- exosome
- fibroblast growth factor 2
- hepatocyte growth factor
- hypoxia
- IFN-γ
- Immunomodulation
- Immunosuppression
- iMSC secretome
- Inflammation
- iPSC-derived MSCs
- Liver cirrhosis
- Macrophages
- malignant pleural mesothelioma (MPM)
- medicine
- mesenchymal stem cells
- Mesenchymal Stromal Cells
- mesothelioma
- nanofiber-hydrogel composite
- neural
- Neuroprotection
- neurospheres
- osteogenic differentiation
- oxygen conditions
- paracrine potential
- Phagocytosis
- placenta-derived mesenchymal stem cells
- Pluripotency
- polyunsaturated fatty acid
- potentiation of iMSC efficacy
- pre-conditioning
- preconditioning
- priming
- quiescence
- rapamycin
- secondary injury
- Secretome
- secretory profile
- spheroids
- spinal cord injury
- umbilical cord
- Vadadustat
- Wharton’s jelly mesenchymal stem cells
- WKYMVm
Links
DOI: 10.3390/books978-3-0365-4995-8Editions