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Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action
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Patient outcomes remain poor for many cancers despite improvements in treatments and new molecular-targeted biomedicines for certain cancer types or subtypes. Dose-limiting toxicity, a narrow therapeutic index, and the development of resistance to traditional anti-cancer agents are well-established. It is apparent that inherent and acquired drug resistance are major challenges with molecular-targeted agents and that on- as well as off-target side effects can still occur. Other issues include drug metabolism by the body and safely supplying a sufficient amount of active drug to the tumor cells. There is a clear and urgent need for new molecular targets and drugs that specifically target cancer cells in different ways to existing approved drugs. This book, through a collection of eight research articles and two review articles from the Biomedicines themed Special Issue ‘Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action’, provides a snapshot of some of the diverse and exciting research approaches being taken by the cancer research community in trying to address some of these therapeutic challenges.
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Keywords
- 5-FU resistance
- 8-hydroxydaidzein
- affibody drug conjugate (AffiDC)
- affibody molecule
- albumin binding domain
- Angiogenesis
- anti-cancer agent
- anticancer drug
- Apoptosis
- AQ4N
- Autophagy
- B-lactam steroid alkylators
- BCR-ABL
- biomarker
- bioprecursor
- Breast cancer
- BxPC-3
- c-myc
- cancer hallmarks
- CCN1
- colorectal cancer
- Connectivity Map
- CYP1A1
- CYP1B1
- CYP2W1
- Cytochrome P450
- DM1
- drug repurposing
- duocarmycin
- EGFR tyrosine kinase inhibitor
- emtansine
- Expression
- Gene silencing
- Genomics of Drug Sensitivity in Cancer
- Glioblastoma
- HepG2
- History of engineering & technology
- Huh7
- human epidermal growth factor receptor 3 (HER3)
- hybrid steroidal alkylating agents
- in vivo imaging
- Invasion
- isatin sulfonamides
- K562
- MAPK
- mesenchymal–amoeboid transition
- microtubule acetylation
- migration
- molecular docking
- n/a
- Nanoparticles
- nanosystems
- NF-κB
- oncogene
- ovarian cancer
- phortress
- photon upconversion
- PLGA
- poly (ADP-ribose) polymerase inhibitors
- prodrug
- RNA interference
- siRNA
- synthetic lethality
- Technology, engineering, agriculture
- Technology: general issues
- triple-negative breast cancer
- triplet-triplet annihilation
Links
DOI: 10.3390/books978-3-0365-5222-4Editions