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Genetics of Prader-Willi syndrome
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Prader–Willi syndrome (PWS) is a complex genomic imprinting disorder associated with a spectrum of medical, cognitive, behavioural, and psychiatric problems and is also the most common cause of life-threatening obesity that can be effectively treated with hormone therapy and restricted diet, if detected early. PWS is usually caused by the loss of the paternally inherited 15q11.2-q13 region and abnormal expression of genes within that region and beyond. While some genotype–phenotype correlations with delineation of clinical characteristics and natural history have emerged when comparing the three main molecular classes of PWS (maternal uniparental disomy (UPD) 15, imprinting centre defect, and deletion of paternal 15q11-q13), better awareness and informative biomarkers are still needed. These could facilitate early diagnosis, counseling, prognostic testing, as well as patient stratification for clinical trials, to improve outcomes for the affected children and their families. This Special Issue will comprise reviews and original research articles focused on the recent advances of genetics/genomics, testing, and epigenetic processes along with clinical description, co-morbidities, and natural history of PWS. Current and future directions with focus on improved screening, diagnosis, and treatment will be addressed in this rare neurodevelopmental genetic imprinting disorder influenced by the PWS genetic subtypes.
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Keywords
- 15q11.2
- age diagnosis
- Animal Models
- appetite treatment
- atypical microdeletion
- Autism
- Bacteria
- blood clots
- BMI
- bone health
- bracing
- Caralluma fimbriata extract
- childhood
- confirmatory ICD-9 diagnostic codes
- cross-sectional
- cytochrome P450 enzymes
- deep venous thrombosis
- Deletion
- Diet
- drug interactions
- eating disorder
- Exercise
- food-related behavior
- Fungi
- Games
- genetic syndrome
- growth hormone treatment
- Gut Microbiota
- Home
- hyperphagia
- hyperphagic obesity
- individuals with exogenous obesity
- insurance health claims
- junctional kyphosis
- KATP channel activation
- kyphosis
- linear mixed models
- major depressive illness
- medication management
- medicine
- Mental illness
- n/a
- Natural history
- Obesity
- Obsessive-compulsive disorder
- Parents
- pediatric
- pharmacogenetic testing
- Prader-Willi syndrome
- Prader-Willi syndrome (PWS)
- Prader–Willi
- Prader–Willi syndrome
- psychiatric behavioral phenotype
- psychosis
- pulmonary embolism
- PWS genetic subtype–phenotype correlations
- PWS molecular classes
- Registry
- Risk factors
- scoliosis
- single-case
- skin picking
- SNORD116
- spinal deformities
- Surgery
- Thromboembolism
- Thrombosis
- treatment options
- uniparental disomy
- Vasculitis
- weight
Links
DOI: 10.3390/books978-3-0365-5026-8Editions