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Personalized Medicine for Parkinson's Disease
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Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
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Keywords
- advanced Parkinson’s disease (APD)
- Alzheimer’s disease
- apomorphine
- apomorphine subcutaneous infusion therapy
- assessment
- carer stress
- cell therapy
- Cerebellum
- Clinical & internal medicine
- Clinical Trial
- clinical trials
- Cognition
- cognitive rehabilitation
- cross-sectional
- Deep Brain Stimulation
- device aided therapies
- device-aided therapies
- Diet
- dopaminergic therapy
- Education
- Emiratis
- epigenetics
- expatriate
- focused ultrasound
- GABAergic signaling
- Gene Therapy
- Genetic
- Genetic Markers
- Genetics
- hematologic tests
- impulsive-compulsive disorders (ICD)
- induced pluripotent stem cells
- insomnia
- Intervention
- intrajejunal
- Levodopa
- levodopa-carbidopa intestinal gel
- lifestyle behaviours
- medicine
- motor and non-motor symptoms
- Movement Disorders
- MRS
- n/a
- neurological disorders
- Neurology & clinical neurophysiology
- non motor symptoms
- non-motor symptoms
- older persons with Parkinson’s disease
- oral health
- Pain
- parkinson’s disease
- Parkinson’s disease (PD)
- Periodontal disease
- periodontitis
- personalised medicine
- personalized medicine
- pharmacogenetic
- PKG (KinetiGrap)
- polymorphisms
- population study
- precision medicine
- Quality of life
- Radiofrequency
- Rehabilitation
- response inhibition
- sleep quality
- societal impact
- Vitamin D
- young onset Parkinson’s (YOPD)
Links
DOI: 10.3390/books978-3-0365-6211-7Editions