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Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer
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This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored experimental and computational techniques as well as their more recently developed counterparts. Molecular insights that can be gained from the papers collected in this issue range from the fundamental to the applied with emphasis on biological functions and biomedical prospects of nucleic acids. The collection is not meant to be exhaustive, but to highlight recent advances from select laboratories worldwide. Nevertheless, it represents a useful guide for scientists who wish to familiarize themselves with biophysical topics in nucleic acid research. This Special Issue will be useful both for researchers who study fundamental aspects of nucleic acid structure, stability, and dynamics, as well as for those that are mainly interested in practical biological and biomedical applications of nucleic acids.
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Keywords
- ab initio methods
- Amber
- aptamer
- ATP sensor
- aurintricarboxylic acid (ATA)
- B-DNA
- biological function and viral disease
- biological structure database
- Biology, Life Sciences
- Biosensor
- brines
- Calorimetry
- CD spectroscopy
- charge
- computational biophysics
- DNA
- DNA conjugate
- DNA curvature
- DNA deformability
- DNA minicircles
- DNA minor groove binder
- DNA sequence context
- DNA sequence-dependent structure
- DNA-hairpin
- DNA-protein networks
- DNAzyme
- Drug Discovery
- drug-like properties
- drug-target interactions
- dsDNA–dsDNA interactions
- electrostatic potential
- enthalpic efficiency
- fitting
- flexibility
- fluctuation theorems
- folding
- forcefield
- fragment-based drug discovery
- G-quadruplex
- G-quadruplexes
- group efficiency
- habitability
- heterocyclic diamidine
- human serum albumin (HSA)
- hydrostatic pressure
- inhibitor binding
- isothermal titration calorimetry
- kinetic models
- kinetics
- Lanthanide
- lead optimization
- ligand
- ligand–DNA complex thermodynamic
- lipophilic efficiency
- mars
- Mathematics & science
- metal ion
- methylene-salicylic acid
- minor groove binding drugs
- mixed base-pair DNA sequences
- molecular curvature
- Molecular Dynamics
- molecular dynamics simulation (MD)
- molecular recognition
- n/a
- NMR spectroscopy
- nucleic acid conformation
- nucleic acid structures
- nucleic acid thermodynamics
- Nucleic acids
- optical spectroscopy
- origins of life
- perchlorates
- polymorphism
- Potassium
- potential of mean force (PMF)
- pressure
- protocells
- quadruplex-duplex hybrids
- Reference, information & interdisciplinary subjects
- replication
- Research & information: general
- RNA
- RNA-dependent RNA polymerase (RdRp)
- salicylic acid polymers
- SARS-CoV-2
- sequence edition
- sequence selectivity
- silver ion
- single-molecule biophysics
- Stability
- Statistical mechanics
- terpyridine
- thermodynamic binding signatures
- Thermodynamics
- Topology
- triple helix
- validation standards
- volume
- yeast ribosomes
Links
DOI: 10.3390/books978-3-0365-6097-7Editions