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Molecular Mechanism and Application of Somatic Cell Cloning in Mammals
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The primary objective of this book is to provide the current status of and new data on the molecular mechanisms affecting the efficacy of somatic cell cloning, but also insightful interpretations of the topical and coming trends in the exploration of genomic, epigenomic, transcriptomic and proteomic profiles for nuclear donor cells, nuclear recipient oocytes and SCNT-derived embryos. Comprehensively deciphering the crucial molecular scenarios responsible for inter-genomic, inter-epigenomic, inter-transcriptomic and inter-proteomic communication within the framework of the aforementioned scenarios might be a milestone giving rise to the enhancements in the extra- and intracorporeal epigenetic reprogrammabilities of donor cell nuclei in nuclear-transferred oocytes, embryos, conceptuses and neonates. In turn, this might allow us to use SCNT-mediated ARTs in such research fields as biotechnology, transgenics, medicine, and biopharmacology, as well as scientific efforts targeted at designing the in vitro and in vivo models of molecular and epigenomic landscapes specific for inheritable and acquired disorders in humans and other mammalian species.
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Keywords
- 3D in vitro maturation
- 5-AZA-dc and TSA epigenetic modifiers
- ACFC line
- apoptotic cell death
- Biology, Life Sciences
- biomedicine
- biopharmacy
- boldenone
- brachygnathia inferior
- Cell Adhesion
- cloned dog
- cloned mammalian embryo
- cumulus cells
- dermal fibroblast cell
- dermal tissue
- domestic goat
- domestic horse
- ECM remodeling
- endocrine-active compounds
- epidermal keratinocyte
- epigenetic reprogrammability
- epigenetic transformation
- equine
- equine chondrocytes
- ex vivo model
- Galα1→3Gal epitope
- gene targeting
- genetically engineered specimen
- genetically modified pig
- Genome editing
- HLA-E
- human α-1,2-fucosyltransferase
- human α-galactosidase A
- Mathematics & science
- Mitochondria
- mitophagy
- molecular pathway
- molecular quality
- mtDNA
- n/a
- nandrolone
- neoplastic transformation
- NGS
- nuclear–mitochondrial interaction
- nucleofection
- nutri-biotechnology
- oncogenic/neoplastic transformation
- oocyte
- ovary
- pig
- porcine skin xenograft
- procancerous tumorigenesis
- putative stem cells
- Reference, information & interdisciplinary subjects
- Research & information: general
- rhα-Gal A
- rhα1,2-FT
- RNA-Seq
- sarcoid
- SCNT-derived embryo
- SCNT-derived progeny
- somatic cell cloning
- Swine
- telomere shortening/attrition
- transcriptome
- tri-genetically modified
- trichostatin A
- whole-genome sequencing
- Wnt Signaling Pathway
- α-Gal antigenic determinant
Links
DOI: 10.3390/books978-3-0365-5965-0Editions