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Pathogenesis and Targeted Therapy of Epilepsy
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Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
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Keywords
- 3-phosphoinositide-dependent protein kinase-1
- 3CAI
- 4-aminopyridine
- acoustically evoked seizures
- Akt
- AMPA receptor
- Anxiety
- astrocyte
- audiogenic epilepsy
- audiogenic kindling
- Behavior genetics
- Blood-Brain Barrier
- c-Fos
- cortical atrophy
- cyclosporin A
- cytokine
- EACT
- early gene activation
- Epilepsy
- epilepsy model
- Epileptogenesis
- fear reaction
- generalized tonic-clonic seizures
- Ghrelin
- ghrelin receptor
- GluA1
- GluR1
- GRIA1
- GRIA2
- hippocampal atrophy
- Hippocampus
- immunofluorescence
- inherited epilepsy
- intracerebral electrode
- intractable epilepsy
- lipopolysaccharide
- long-term potentiation
- Magnetic Resonance Imaging
- Mathematics & science
- ML365
- mural cells
- n/a
- neuroinflammation
- neuronal activity
- neuropsychiatric comorbidity
- PDK1
- pentylenetetrazole
- pericytes
- pharmacoresistant epilepsy
- Physics
- PICK1
- post-traumatic epilepsy
- posttraumatic epilepsy
- Protein Kinase C
- Reference, information & interdisciplinary subjects
- refractory seizure
- Research & information: general
- Rodents
- seizure susceptibility
- Temporal Lobe Epilepsy
- TMEM1A channels
- Traumatic Brain Injury
- TRPV1 channels
- wild running seizures
Links
DOI: 10.3390/books978-3-0365-6437-1Editions