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Human Papillomavirus and Head and Neck Cancer
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In the study of head and neck squamous cell carcinoma (HNSCC), we know that virally induced malignancies behave differently than those generated through other carcinogenic mechanisms. This paradigm extends into differences in tumor growth, treatment response and resistance, as well as invasion and metastasis. The inability to correctly diagnose and appropriately treat HNSCC at early stages has contributed to reduced survival for HNSCC patients, particularly those with HPV-negative disease. The examination of the molecular differences between HPV-positive and HPV-negative HNSCC will provide support for early diagnostic markers and guide appropriate treatment selection to improve patient care and survival.This Special Issue highlights current research efforts to understand the evolving contribution of human papillomavirus in HNSCC.
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Keywords
- anatomic subsite
- Apoptosis
- APOT-PCR
- Autophagy
- biomarkers
- Cancer
- cancer stem cells (CSCs)
- cancer subtypes
- capture-based assay
- CD1a
- community detection algorithm
- consequences of HPV integration
- CSC markers
- Detection method
- DFS
- diffusion-weighted
- DIPS-PCR
- DNA Methylation
- dynamic contrast-enhanced
- ER/mitochondrial photosensitizer
- extracellular vesicle
- fast exchange regime model
- fish
- Foxp3
- Gene expression
- Glycolysis
- Head and Neck Cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell carcinomas
- hematological parameters
- high-risk human papillomaviruses
- HPV
- HPV integration
- human papillomavirus
- human papillomavirus (HPV)
- human papillomavirus diagnosis
- immune cells
- Immune response
- immune status
- keratinization
- kinetic modeling
- Langerhans cells
- Metabolism
- OPSCC
- oropharyngeal cancer
- oropharyngeal cancer (OPC)
- oropharyngeal squamous cell carcinoma
- oropharynx
- os
- overall survival
- oxidative phosphorylation
- p16
- p53
- paraptosis
- PCR
- photodynamic therapy
- positron emission tomography
- Prevalence
- prognosis
- prognostic
- proteomic
- Radiotherapy
- recurrence
- RNAseq
- sinonasal squamous cell carcinoma
- spin-glass model
- Staging
- Survival
- T regulatory lymphocytes
- TATI
- Technology, engineering, agriculture
- Technology: general issues
- TNM
- tonsillar cancer
- transposable elements
- tumor heterogeneity
- viral DNA integration
- virus-related cancers
- WES
- wgs
Links
DOI: 10.3390/books978-3-0365-6704-4Editions