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Plant and Marine-Derived Natural Product Research in Drug Discovery: Strengths and Perspective
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For centuries, nature has been an inspirational source for the discovery of drugs used in modern medicine. Nowadays, natural-based treatments continue to be employed for primary health care, particularly playing a significant role in folk medicine. In addition, we are currently observing an increasing use of natural-products-based supplements from botanical and marine sources, making their standardization and scientific validation a priority to guarantee the safety of these products. Natural products and/or synthetic derivatives using their novel structures have also been of utmost importance in drug discovery and development in several clinical areas. After a period of discreditation and reduced investment, we are now witnessing a renewed interest from the pharmaceutical industry and scientific community due to the urgent need to develop new drugs. This reprint comprises 11 original and 6 review articles dedicated to plant and marine natural products research, contributing to the scientific validation of their use and opening new perspectives in drug discovery
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Keywords
- (−)-usnic acid
- 2D NMR analyses
- 7α-acetoxy-6β-hydroxyroyleanone
- Adipogenesis
- alkaline extraction
- amphotericin B
- Anthocyanins
- Antibacterial activity
- anticancer activity
- antifungal activity
- antimicrobial activity
- antioxidant
- Antioxidants
- antitumoral activity
- Asphodelus ramosus
- Autophagy
- bioactivities
- bioavailability
- biological activity
- biosynthesis
- Bursera graveolens
- candidiasis
- Cardiovascular medicine
- cellulite
- Chagas Disease
- Chemotaxonomy
- Clinical & internal medicine
- collagenase inhibition
- Cytotoxicity
- Database
- diabesity
- dietary source
- Endoplasmic Reticulum Stress
- ent-abietane
- essential oil
- ethosomes
- Euphorbia
- evernic acid
- Flavonoids
- fructans
- fructooligosaccharide
- Garcinia indica
- gel
- herbal medicine
- high-performance thin layer chromatography
- human African trypanosomiasis
- human American trypanosomiasis
- Hymenocardia acida
- IL-1β
- Infrared spectroscopy
- inulin
- ischemic stroke
- isofuranodiene
- Kidney
- kokum
- lichen extracts
- linarin
- lipid accumulation
- lipolysis
- Mass Spectrometry
- medicine
- Melatonin
- monoterpenes
- mycosporine-like amino acids (MAAs)
- mycosporines
- n/a
- NAFLD
- nanoencapsulation
- nanoparticle
- NF-ĸB
- NMR spectroscopy
- pharmacological activities
- pharmacological activity
- photoprotective compounds
- phytochemistry
- Plant extract
- Plectranthus
- PLGA
- Posidonia oceanica
- propyl-propane-thiosulfinate
- propyl-propane-thiosulfonate
- root-tubers
- royleanone
- salazinic acid
- Sambucus nigra L.
- secondary metabolites
- skin compatibility
- sleeping disease
- Smyrnium olusatrum L.
- structure–activity relationship
- terpenoids
- Thai herbal compress
- TNF-α
- topical treatment
- Trypanosoma
- UV-absorbing compounds
- vapor
- vasorelaxation
- wild mangosteen
Links
DOI: 10.3390/books978-3-0365-6810-2Editions