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Molecular Mechanisms of Steroid Hormone Biosynthesis and Action
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Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones.
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Keywords
- 11-oxygenated androgens
- 20-hydroxyecdysone (20E)
- AAV9
- activator protein 1
- Adrenal Cortex
- adrenal gland inner cortex
- adrenocortical carcinoma
- aldo-keto reductase
- AMPK
- androgens
- ANKRD1
- bile acid
- bile acids
- bZIP factors
- CAMKI
- CEBPB
- Cell Differentiation
- cholesterol
- cholesterol esters
- cholesterol transport
- congenital adrenal hyperplasia
- cow
- CREB
- CTGF
- CYR61
- deficiency
- Development
- DHCR24
- DNA–protein interactions
- EDC mixtures
- Endocrine Disruptors
- Enhancer
- Erk1/2
- fetal Leydig cells
- follicle deviation or divergence
- follicle-stimulating hormone
- GATA
- GATA4
- Gene expression
- glucocorticoid receptor
- Hippo
- Hippo signaling
- histone deacetylase inhibitor
- hydroxysteroid dehydrogenase
- in utero exposures
- insulin-like 3
- LATS1/2
- LC-MS/MS
- Leydig cell
- Leydig cells
- LH
- LH-receptor
- linker-scanning mutagenesis
- luteinizing hormone
- Macrobrachium nipponense
- Maintenance
- medicine
- MEF2 factors
- method validation
- MnHR4
- molt
- NR5A1
- nuclear receptors
- ovary
- phosphoproteomics
- pituitary gonadotrope
- PKA
- prostate cancer
- Proteomics
- pseudohermaphroditism
- RNA interference
- seladin-1
- Sertoli cells
- signaling cascade
- Single nucleotide polymorphism
- Spermatogenesis
- star
- steroid hormones
- steroid reductase
- steroidogenesis
- steroidogenic acute regulatory protein
- sterol carrier protein 2
- sterol carrier protein-x
- Structure-function
- testicular function
- testis
- Testosterone
- TGR5
- thrombospondin-2
- transcription
- Transcription Factors
- transcriptome analysis
- transgenic mice
- transgenic mouse model
- X-zone
- yes-associated protein 1
Links
DOI: 10.3390/books978-3-0365-7002-0Editions