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Impacts of Molecular Structure on Nucleic Acid-Protein Interactions
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Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexibility. Current knowledge demonstrates that the structural conformations of nucleic acids play critical roles in protein–DNA interactions. This book presents a collection of research findings published in the Special Issue of the International Journal of Molecular Sciences, titled “Impacts of Molecular Structure on Nucleic Acid-Protein Interactions”.The breadth of research findings reported here demonstrates that the structural flexibility of nucleic acids plays critical roles in their interactions with proteins, with important implications across a range of human diseases, including cancer and some infectious diseases.Prof. Richard BowaterUniversity of East Anglia, Norwich, United KingdomProf. Václav BrázdaInstitute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic
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Keywords
- 1.688 repeats
- 372-bp repeats
- Aging
- agnostic
- Algorithm
- amino acid composition
- arithmetic operation
- Biochemical engineering
- Bioinformatics
- Biotechnology
- Canton-S
- chromosome fragility
- circular dichroism
- CNBP
- coevolution
- comparative analysis
- Coronavirus
- COVID-19
- cruciform
- DNA
- DNA base sequence
- DNA structure
- DNA supercoiling
- Drosophila
- dsDNA
- ectopic pairing
- epigenetics
- Evolution
- fragile X syndrome (FXS)
- fragile X-associated primary ovarian insufficiency (FXPOI)
- fragile X-associated tremor/ataxia syndrome (FXTAS)
- G-quadruplex
- G4Hunter
- genome stability
- host
- i-motif
- inverted repeat
- ligand
- Longevity
- molecular computing
- Nucleic acids
- nucleic acid–protein interactions
- orthogonal representation
- p53
- plant science
- polytene chromosomes
- protein binding
- protein sequence
- repeat expansion
- repeat instability
- repeat-associated non-AUG (RAN) translation
- repeat-mediated gene silencing
- replication
- reversible computing
- rhodamine
- RNA
- RNA gain-of-function
- RNA–RNA interaction
- SARS-CoV-2
- Technology, engineering, agriculture
- Technology: general issues
- thiazole orange
- thioflavin T
- toehold switch
- transcription
- triplex
- UV light
- virus
- Z-DNA
- Z-RNA
- Zα domain
Links
DOI: 10.3390/books978-3-0365-7444-8Editions