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Molecular and Clinical Advances in Understanding Early Embryo Development
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This reprint considers a wide variety of topics concerning molecular and clinical advances in understanding early mammalian embryo development. The authors of various chapters of this book examine oocyte biology, preimplantation embryo development, blastocyst implantation in the uterus, and second cellular lineage differentiation. In addition, epigenetic contributions to reproduction, which may occur throughout pregnancy and in resultant offspring, are also considered. Environmentally induced epigenetic changes in germ cells can render mammalian offspring less healthy, and these changes can be difficult to reverse. Included in these changes are those caused by assisted reproductive technologies (ARTs). It remains to be determined whether the healthiest preimplantation embryos develop in vitro in conditions that mimic the physiological environment in vivo or whether simpler conditions can also foster this development in vitro. In this regard, a number of advances as well as challenges in ART are considered by the authors of the chapters included in this book.
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Keywords
- amino acid metabolism
- amino acid transport
- amino acid transporter
- amino acid transporters
- assisted reproductive technologies (ARTs)
- autologous mitochondrial transfer
- B0AT1
- bovine preimplantation development
- cardiometabolic health
- Childhood obesity
- CRISPR/Cas9
- cynomolgus monkey
- decidualization
- diabetes
- DOHaD
- domain segregation
- Electron microscopy
- embryo
- embryo development
- Embryogenesis
- Embryos
- epiblast
- epigenetic modification
- epigenetic modifications
- epigenetics
- ESRRB
- extracellular vesicles
- Fertility
- follow-up
- germinal vesicle
- H3K27 methylation
- Human
- In vitro fertilisation
- in vitro fertilization
- in vitro maturation
- lifestyle intervention
- long noncoding RNA
- MacERV6-LTR1a
- maternal obesity
- Medical equipment & techniques
- medicine
- Medicine: General Issues
- MEK
- miR-155
- Mitochondria
- mitochondrial DNA (mtDNA)
- mitochondrial replacement therapy (MRT)
- mitochondrial score
- mouse
- n/a
- Nanog
- offspring
- oocyte
- oogenesis
- pipecolic acid
- porcine embryo culture
- preimplantation embryo
- primitive endoderm
- Programming
- Proline
- rabbit
- recurrent spontaneous abortion
- ROCK inhibitor
- second lineage differentiation
- sequence
- Slc6a19
- SOX17
- trophectoderm
- ZGA and implantation
Links
DOI: 10.3390/books978-3-0365-7492-9Editions