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Nanoparticles in Ocular Drug Delivery Systems
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Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity.To increase the residence time of formulations on the surface of ocular tissues and increase their ability to penetrate these tissues, different strategies can be used, namely, the use of viscosifying agents, mucoadhesive polymers, stimuli-responsive polymers, microparticles, and colloidal carriers (e.g., micelles, liposomes, nanosuspensions, nanoemulsions, polymeric, and lipid nanoparticles). This Special Issue combines the latest research and review works reporting the use of nanoparticles in ophthalmic formulations to increase their bioavailability and improve the therapeutic efficacy of ophthalmic formulations.
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Keywords
- 3D bioprinting
- autoclave
- barriers of corneal tissues
- Box Behnken design
- cannabidiol
- carbopol® 940 NF
- Cell-Penetrating Peptides
- chitosan
- ciprofloxacin
- conjunctivitis
- corneal tissue engineering
- corticosteroids
- cosolvent
- cyclodextrin
- cyclosporine A
- Diagnostics
- Economics, finance, business & management
- Encapsulation
- Endothelium
- Epithelium
- flash nanoprecipitation
- fluorescence
- fosinopril sodium
- fungal keratitis
- Glaucoma
- hyaluronic acid
- Hydrogels
- in situ gel
- indocyanine green
- Industry & industrial studies
- inner limiting membrane
- IOP
- kappa-carrageenan
- kill kinetics
- linoleic acid
- Manufacturing industries
- media milling
- medicine
- microcarriers
- mucoadhesion
- n/a
- nanocarriers
- Nanocrystals
- nanoemulsion
- nanoparticle drug-delivery systems
- Nanoparticles
- Nanotechnology
- nebivolol
- niosomes
- ocular bioavailability
- ocular delivery
- ocular diseases
- ocular drug delivery
- ocular inflammation
- open-angle glaucoma
- ophthalmic
- Pharmaceutical industries
- photodisruption
- PKS
- Poloxamer-407
- probes
- pulsed laser
- Rabbits
- retinal drug delivery
- spanlastics
- stabilization
- stroma
- susceptibility
- sustained ocular delivery
- therapeutic efficacy
- therapeutic proteins
- tolnaftate
- topical ocular drug delivery
- transferosomes
- triamcinolone acetonide
- vapor nanobubbles
- zein
Links
DOI: 10.3390/books978-3-0365-8002-9Editions