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Genetics and Epigenetics in Complex Diseases
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Many of the most common diseases are influenced by a combination of multiple factors, which include environmental effectors as well as genetic and epigenetic variations. Therefore, these diseases are grouped under the term “complex” diseases because, from the point of view of genetics, they cannot be explained by simple Mendelian inheritance. The aim of this special issue was to identify genetic and epigenetic factors involved in such diseases in order to improve not only the knowledge of risk factors for those diseases, which could be of help for prevention, but also the understanding and characterization of each disease and to optimize and personalize the treatment.
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Keywords
- acute lymphoblastic leukemia
- acute myeloid leukemia
- all-cause mortality
- Alzheimer’s disease
- Biology, Life Sciences
- body shape indices
- bone density
- Cancer
- candidate gene association studies
- CD33
- chromatin remodeling
- chromosome instability
- chronic lymphocytic leukemia
- circular RNA
- CLL
- cohesin complex
- comorbidities
- complex disorders
- COPD
- coronary artery disease
- CUL1
- diabetes
- differential effect
- DNA Methylation
- Family Studies
- FBXO5
- FBXW7
- Genetic architecture
- genetic variants
- Genetics
- Genetics (non-medical)
- genome instability
- genome-wide studies
- germline cancer predisposition
- histone modification
- IKAROS
- KLF14
- Life sciences: general issues
- major adverse cardiac events
- Mathematics & science
- MD
- metabolic traits
- n/a
- NF-κB
- non-coding RNA
- Notch
- Obesity
- Oncogenes
- PD
- pediatric
- Phagocytosis
- POT1
- psoriasis
- psoriatic arthritis
- Pulmonary Tuberculosis
- RAD21
- RBX1
- Reference, information & interdisciplinary subjects
- Research & information: general
- resistin
- rs4588
- rs7041
- SCF complex
- SF3B1 mutation
- shelterin complex
- sialic acid
- SKP1
- SKP2
- SNP
- soluble suppression of tumorigenicity 2
- susceptibility
- syncope
- Taiwan biobank
- thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
- trio sequencing
- tumor suppressor genes
- tumor virus
- twin studies
- vasovagal syncope
- VDBP
- vitamin D binding protein
- weighted genetic risk score
Links
DOI: 10.3390/books978-3-0365-7856-9Editions