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Ophthalmic Drug Delivery
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Research in ophthalmic drug delivery has developed significant advances in the last few years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies.
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Keywords
- age-related macular degeneration
- albumin
- amphotericin B
- anti-angiogenesis
- ARPE-19
- atropine
- biotin-decorated nanoparticles
- blood-retinal barrier
- cationic drug
- CNTF
- controlled drug release
- corneal neovascularization (NV)
- corticosteroids
- cyclodextrins
- cytotoxicity studies
- dexamethasone
- dexamethasone acetate
- dissolution
- Drug delivery
- Drug delivery systems
- dry eye
- Economics, finance, business & management
- Electric Cell-Substrate Impedance Sensing
- epigallocatechin gallate (EGCG)
- excitotoxicity
- eye drops
- eyelid
- fasudil
- fungal keratitis
- gamma sterilization
- Gelatin
- Gene Therapy
- Glaucoma
- half-life extension
- hyaluronic acid (HA), nanoparticles
- Hydrogels
- in vitro drug release
- in vitro model
- Industry & industrial studies
- intravitreal administration
- intravitreal delivery
- intravitreal dexamethasone implant
- intravitreal implants
- intravitreal injection
- intravitreal injections
- Iron
- lutein
- lysosomal trapping
- macular edema
- Manufacturing industries
- medicine
- microparticles
- microspheres
- mucin
- Myopia
- neurodegeneration
- Neuroprotection
- ocular drug delivery
- ocular drug delivery systems
- ocular pharmacokinetics
- ocular routes of drug administration
- ophthalmic solution
- Ophthalmology
- Ozurdex
- periocular administration
- Pharmaceutical industries
- plasmid electrotransfection
- PLGA
- PLGA microspheres
- PLGA–PEG–biotin
- poly(lactic-co-glycolic) acid
- polymeric nanoparticles
- protein aggregation
- radiolabeled ocular biopermanence
- rebamipide
- Retina
- Retinal degeneration
- retinal penetration
- retinal pigment epithelium
- retinitis pigmentosa
- RGD peptide
- rheology
- ROCK inhibitor
- Schlemm’s canal
- size exclusion chromatography
- SLA 3D-printing
- Stability
- sustained delivery system
- targeted therapy
- therapeutic proteins
- tolerance
- topical administration
- trabecular meshwork
- transcorneal permeation
- transferrin
- transport
- triamcinolone acetonide
- USP apparatus 4
- USP apparatus 7
- vitreous substitute
- γ-cyclodextrins
Links
DOI: 10.3390/books978-3-0365-8796-7Editions