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Ophthalmic Drug Delivery, 2nd Edition
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Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies.
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Keywords
- acanthamoeba keratitis
- amantadine
- aniridia
- anterior chamber
- anti-biofouling
- aqueous solubility
- ataluren
- besifloxacin
- blood–retinal barrier
- chemical stability
- clinical studies
- compounded formulation
- conjunctivitis
- contact lens
- container-content interaction
- controlled drug delivery
- corneal ecstatic disorder
- cysteamine
- cystinosis
- Distribution
- drug concentration
- Drug delivery
- Drug Repositioning
- Economics, finance, business & management
- electrospinning technique
- electrospun fibers
- endotoxin-induced uveitis
- Experimental models
- Eye
- eye drops
- fluoroquinolones
- Glaucoma
- gold nanoparticles
- hyaluronic acid
- hydroxypropyl-β-cyclodextrin
- immunosuppressants
- Industry & industrial studies
- inner BRB
- Interleukins
- intracameral injection
- intraocular lens
- intraocular lenses
- intraocular pressure
- intravitreal
- intravitreal half-life
- keratoconus
- lactoferrin
- leachable compound
- lens epithelial cells
- liposomes
- Macular Degeneration
- Manufacturing industries
- medicine
- melanin
- Method
- micro-pattern
- microsphere
- miltefosine
- Nanocrystals
- Nanoparticles
- nanoprecipitation
- NMDA receptor
- ocular
- ocular drug delivery
- ocular hypertension
- ocular implants
- ophthalmic administration
- ophthalmic solution
- outer BRB
- Pathophysiology
- Permeability
- pet
- PET/CT imaging
- Pharmaceutical industries
- pharmacokinetics
- photodynamic therapy
- photothermal therapy
- physicochemical stability
- pigment
- PLGA
- poly ε-caprolactone
- posterior capsular opacification
- posterior capsule opacification
- Povacoat®
- prostaglandin analogues
- protein nanocarriers
- rare disease
- rat
- Retina
- retinal capitally endothelial cells
- Retinal disease
- retinal explants
- retinal pigment epithelial cells
- retinal pigment epithelium
- rivoceranib
- Stability
- subfoveal choroidal neovascularization
- Surface modification
- sustained drug release
- tacrolimus
- tissue isolation
- topical ophthalmic administration
- trabecular meshwork
- transporter
- Ussing chamber
- uveitis
- Wound healing
Links
DOI: 10.3390/books978-3-0365-8798-1Editions