Explore
![Recent Developments in Myelodysplastic Syndromes Recent Developments in Myelodysplastic Syndromes](https://unglueit-files.s3.amazonaws.com/cache/9d/5a/9d5aff49e515f2386872ba4fbde2bb52.jpg)
Recent Developments in Myelodysplastic Syndromes
Ota Fuchs (editor)
2019
0 Ungluers have
Faved this Work
Login to Fave
This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.
This book is included in DOAB.
Why read this book? Have your say.
You must be logged in to comment.
Rights Information
Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.Downloads
This work has been downloaded 9 times via unglue.it ebook links.
- 9 - pdf (CC BY) at mts.intechopen.com.
Keywords
- Clinical & internal medicine
- Diseases & disorders
- medicine
- oncology
- thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
Links
DOI: 10.5772/intechopen.73936Editions
![edition cover edition cover](https://unglueit-files.s3.amazonaws.com/cache/9d/5a/9d5aff49e515f2386872ba4fbde2bb52.jpg)