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Porcine Models of Neurotrauma and Neurological Disorders
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The translation of therapeutics from the lab to the clinic has a dismal record in the fields of neurotrauma and neurological disorders. This is due, in part, to the challenging heterogeneity of the clinical population common to all translational research, but it is also due to the unique challenges of recreating the mechanisms and manifestations of human neurological injury/disorders in small animals. Large animal models are an essential component of successful pipelines for moving discoveries from bench to bedside in other fields (e.g., exploring device or therapeutic scale-up and/or IND/IDE enabling studies), and neuroscience has made significant progress toward establishing such pipelines in its many unique subfields. Due to their size, gyrencephalic brains, high white matter content, and other factors, swine have proven to be ideal for providing high-fidelity, clinically relevant studies to bridge the gap between small animals and humans. Only by recognizing the strengths and limitations of our models can we hope to effectively develop, validate, and translate novel neuroprotective and regenerative therapeutics into clinical practice, in order to maximize functional recovery. Herein, we provide detailed descriptions of and findings from some of the sophisticated swine model systems that have been developed to empower translational research in neurotrauma and neurological disorders.
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Keywords
- acquired brain injury
- aged tissue
- Alzheimer’s disease
- Animal Models
- Astrocytes
- auditory evoked potentials
- auditory perception
- axonal injury
- balloon compression technique
- Behavior
- brain concussion
- Brain Injury
- Cognition
- Coma
- concussion
- contusion
- diagnostic methods
- diffuse pathology
- disorders of consciousness
- electrodes
- fibrinogen
- Gait
- Gastrointestinal Motility
- glia
- hemisection
- large animal
- large animal models
- micro pig
- Microglia
- mild TBI
- mild traumatic brain injury (mTBI)
- multimodal neuromonitoring
- n/a
- neurocritical care
- neuroinflammation
- neurointensive care unit
- neurotrauma
- oculomotor
- operant
- pediatric
- phosphorylated tau
- Physiology
- pig
- PNT001
- porcine
- porcine model
- porcine models
- pupillary light response
- rapid non-impact head rotation
- Regeneration
- SmartPill™, wireless motility capsule
- spinal cord injury
- Subarachnoid Hemorrhage
- Swine
- tau
- TBI
- thema EDItEUR::M Medicine and Nursing
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
- transgenic
- translational neuroscience
- translational neurotrauma
- traumatic brain injuries
- Traumatic Brain Injury
- Visual perception
- Visual Processing
- visually evoked potentials
Links
DOI: 10.3390/books978-3-7258-0506-8Editions