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The Mode of Actions of the Current Point-of-Care Treatments for Osteoarthritis of the Knee
Masato Sato (editor)
2024
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Point-of-care treatments are now the focus of attention for osteoarthritis of the knee (OAK). Cellular therapies, which can be performed on an outpatient clinic basis, are rapidly expanding in free practice. Platelet-rich plasma (PRP) therapy for OAK is a prime example of such therapies. It is seen as an unmet medical need that fills the gap between surgical and conservative therapy. In other words, even though it is not an innovative regenerative medicine and cannot improve the disease itself by modifying the tissue structure, point-of-care cell therapy appears to have become an established treatment, advanced by patients' desire for some improvement in symptoms without the need for surgery. This Special Issue covers the current use of point-of-care therapies and potential future candidates, from basic research to clinical practice.
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Keywords
- anti-adhesive membrane
- arthrofibrosis
- autologous anti-inflammatory
- autologous protein solution
- BMP-2
- bone remodeling
- cartilage
- cartilage regeneration
- cell sheet
- cell therapy
- concentrated bone marrow aspirate
- Diagnosis
- disease modifying drugs
- disease-modifying osteoarthritis drug
- E8002
- Embryonic Stem Cells
- exosome
- Gene Therapy
- hyaluronic acid
- induced pluripotent stem cells
- Inflammation
- injection
- intra-articular injection
- Knee
- knee adhesion
- knee joint
- knock-in mice
- macrophage
- Management
- mechanism of action
- mesenchymal stem cells
- minimally invasive treatment
- mode of action
- MSC
- myofibroblast
- nerve growth factor (NGF)
- oligonucleotide therapeutics
- Osteoarthritis
- osteoarthritis of the knee
- ozone
- Pain
- platelet rich plasma
- platelet-rich plasma
- point-of-care therapy
- PRG-4
- silent information regulator 2 ortholog 1 (SIRT1)
- Surgery
- synovial fluid
- synovium
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
- TSG-6
Links
DOI: 10.3390/books978-3-7258-1107-6Editions