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Engineering and Characterisation of Novel Nanomedicine Formulations
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Over the last few decades, nanomedicine has become a hot topic in formulation science regarding selectively delivering drugs to target tissues. Nanomedicines can modify drug release and encapsulate poorly soluble drugs, allowing for a selective targeting and minimizing adverse effects. This is of key importance in antitumoral and anti-infectious therapies, in which undesired drug release can lead to severe damage to healthy tissues. Moreover, they protect drugs from degradation, allowing for the the delivery of RNA. This reprint encompasses works describing the design, development and characterization of lipid nanomedicines, dendrimers and virus nanoparticles among others, as well as the evaluation of their toxicity and their anticancer and antifungal efficacy. Moreover, it analyzes the quality assessment of nanomedicines under clinical investigation.
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Keywords
- acute myeloid leukemia
- acute toxicity
- Ang-(1-7)
- antifungal
- biological fluids
- biological identity
- Biological properties
- bone marrow targeting
- Breast cancer
- Cancer
- Candida albicans
- cardiac ischemia/reperfusion
- cisplatin
- clinical trials
- coencapsulation
- Copper
- Cytotoxicity
- dendrimer generation
- Diffusion
- doxorubicin
- Drug delivery
- Engineering
- ethosome
- Exosomes
- flow field flow fractionation (FFF)-multidetection
- functional cyclized polyethylene glycol
- fungal infection
- hybrid nanoparticles
- hydrogel
- hyperthermia treatment
- hypoxia
- intravenous administration
- investigational medicinal products
- liposomes
- Magnetic nanoparticles
- Manufacture
- Mas receptor
- metal complexes
- metastasis
- metastatic potential
- Microfluidics
- n/a
- nanocarrier
- Nanomedicine
- nanoparticle
- native characterization
- non-replicating rotavirus vaccine
- norovirus S60 nanoparticle
- PAMAM dendrimer
- PEGylation of laponite
- perylenediimide
- pH-sensitive liposomes
- protein corona
- Quality
- rate of drug release
- Regulatory
- rotavirus
- rotavirus vaccine
- rotavirus VP8*
- S60-VP8* pseudovirus nanoparticle
- scale-up
- Silver
- simvastatin
- siRNA lipid nanoparticles (LNPs)
- skin permeation
- solid lipid nanoparticles
- solid tumors
- Surface chemistry
- targeted delivery
- terbinafin
- thema EDItEUR::M Medicine and Nursing
- thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQP Pharmacy / dispensing
- Toxicity
- triple negative breast cancer
- very-late antigen-4 (VLA-4)
- Zingiber zerumbet Linn
Links
DOI: 10.3390/books978-3-7258-1095-6Editions