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Antimicrobial Biomaterials: Recent Progress
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Biomaterials can be used as implantable devices or drug delivery platforms with a significant influence on a patients’ quality of life. Indeed, every year a substantial number of new biomaterials and scaffolding systems are engineered and introduced in the biomedical field with increased potential for biomedical uses. However, their long-term use can be threatened by the adhesion and proliferation of microorganisms, which can interact and form biofilms, or the formation of fibrosis, with cytotoxic responses being very common. Pathogenic microorganisms may cause local infection and consequent implant failure; furthermore, they can hinder the delivery of therapeutic molecules by specialized delivery platforms, turning them ineffective. Many alternatives have been proposed over the years to prevent such events, including the use of antiseptics and antibiotics or the physical modification of the biomaterial surface, with the incorporation of biomolecules of interest. From specialized polymers and functional groups to silver and, more recently, antimicrobial peptides and natural extracts, different functionalization/modification techniques have been employed in this fight against pathogenic agents.
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Keywords
- 1H-benzo[d]imidazole derivatives
- ADME
- Ag@AgCl nanoparticles
- AMP-releasing
- anti-tuberculosis therapy
- Antibacterial activity
- antibacterial chains
- antibacterial nanoformulations
- antibacterial property
- antibiotic combinations
- antibiotic resistance
- antibiotics impregnated
- antifungal nanoformulations
- antimicrobial
- antimicrobial activity
- antimicrobial coatings
- antimicrobial peptide
- antimicrobial resistance
- antimicrobial therapy
- antimicrobials delivery
- antimycobacterial
- antioxidant
- antiparasitic nanoformulations
- antiviral nanoformulations
- Bacteria
- benzoxaborole
- Biocompatibility
- Biofilm
- biomaterial
- cell infection assays
- cellobiose dehydrogenase
- chitosan
- chitosan nanoparticles
- click chemistry
- CO2 laser
- crossing the blood–brain barrier
- Cytotoxic
- Cytotoxicity
- Dental Plaque
- Drug delivery systems
- drug resistance
- dye reduction
- elastomeric chainswhite spot lesions
- Enterococcus faecalis
- enzyme activity
- erbium laser
- external ventricular drain
- fruit quality parameters
- fungicidal activity
- genomic DNA
- HaCaT cells
- hydrogel
- immobilization
- Infectious Disease
- isoniazid
- microbial activity
- Molecular diagnosis
- molecular docking
- multidrug resistance
- multidrug-resistant tuberculosis
- Mutation
- n/a
- nanocarriers
- Nanoparticles
- Nitric Oxide
- oral pathogens
- orthodontic brackets
- orthodontic ligatures
- phosphoric acid
- photopolymerization
- porosity
- porous silica spheres
- preharvest treatments
- quaternization
- real-time PCR
- rifampicin
- S-Nitroso-N-Acetylpenicillamine (SNAP)
- self-assembling
- Shewanella sp.
- Silver
- silver nanoparticles
- skin pathogens
- SNAP
- soy protein isolate
- Streptococcus mutans
- Streptococcus sanguinis
- structure–activity relationship
- surface area
- sweet orange essential oil
- synthesis mechanisms
- thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine
- Tuberculosis
- vitreous enamel
- Wound healing
- X-ray
- yellow everzol textile dyes
Links
DOI: 10.3390/books978-3-7258-1659-0Editions