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Molecular Mechanism of Alzheimer's Disease
Ian Macreadie
2019
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Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.
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Keywords
- 4
- 5-trisphosphate receptor
- ?-secretase
- A?O receptors
- aggregation
- Alzheimer’s disease
- amyloid ?
- amyloid beta
- amyloid-? oligomer
- APOE gene
- apolipoprotein E
- beta amyloid
- brain glucose metabolism
- calcium signaling
- CDK5R1
- cognitive behavioral therapy for insomnia
- Cognitive function
- complement
- complement C3b/C4b receptor
- complement receptor 1
- CR1 density
- CR1 length polymorphism
- cystathionine-?-lyase CTH gene
- dairy products
- default-mode network
- Dementia
- dendritic spine
- DNA Methylation
- drug target discovery
- Endoplasmic Reticulum
- epigenetics
- epigenome-wide association study
- genetic risk
- heat shock protein
- heat shock response
- Hispanics
- HOTAIR
- Inflammation
- inositol 1
- inositol 1,4,5-trisphosphate receptor
- ion channel
- lncRNAs
- magnetic resonance imaging (MRI)
- MALAT1
- methylenetetrahydrofolate reductase MTHFR gene
- methylome
- Microglia
- Mild Cognitive Impairment
- miR-15/107
- miR-34c
- Molecular biology
- NEAT1
- neurodegeneration
- neuronal degeneration
- neuronal differentiation
- Neurosciences
- Nutrition
- oligomerization
- Oxidative Stress
- Pin1
- positron emission tomography (PET)
- prion
- Prolyl isomerases
- protein aggregation
- proteostasis
- ryanodine receptor
- S-adenosylmethionine
- sleep disturbance
- sleep fragmentation
- slow-wave sleep
- tau
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
- Therapy
- type 2 diabetes
- type 3 diabetes
- Ubiquitin
- vitamin B complex
- Yeast
Links
DOI: 10.3390/books978-3-03921-408-2Editions
