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Major Histocompatibility Complex (MHC) in Health and Disease
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The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
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Keywords
- 3??5? mRNA turnover
- 5??3? RNA decay
- ?2m knockout mice
- ancestral haplotype
- ankylosing spondylitis
- antigen
- antiviral immunity
- astrogliosis
- autoimmune disease
- Autoimmune Diseases
- Autoimmunity
- Bactrian camel
- Birds
- BK virus
- bottleneck
- camels
- Cancer
- competing endogenous RNA (ceRNA)
- computational analysis
- concerted evolution
- conservation genetics
- crested ibis
- cynomolgus macaque
- disease association
- Disease Resistance
- DOM3Z
- domain movements
- dromedary
- DXO
- Ecology
- ethnic populations in China
- Evolution
- Exosomes
- Experimental Medicine
- Expression
- fish
- founder effect
- gene duplication
- Genetic Drift
- Giant panda
- haplotype
- HCP5
- hepatocellular carcinoma
- high-throughput sequencing
- HLA
- HLA polymorphism
- HLA-B27
- human endogenous retrovirus (HERV)
- human immunodeficiency virus (HIV)
- human leukocyte antigen-E
- human papillomavirus (HPV)
- interferon ?
- kidney transplantation
- KIR
- KIR–HLA pairs
- Life history
- lncRNA
- long-fragment super haplotype
- long-read sequencing
- Macaca fascicularis
- major histocompatibility complex
- major histocompatibility complex (MHC)
- Melanoma
- MHC
- MHC genes
- MHC polymorphism
- MHC-I- and MHC-II-dependent inter-individual recognition
- MHC-I-based mother-fetus recognition
- MHC-II-associated sperm-egg recognition
- micro-mini-pigs
- microglial reaction
- miR1236
- molecular dynamics simulation
- n/a
- NELF-E
- nephropathy
- nonclassical
- nonhuman primate models
- NSDK
- nuclear kinase
- Old World camels
- orthology
- pedigree
- phase
- PNS/CNS interface
- polymorphism
- polyomavirus
- production trait
- promoter-proximal transcriptional pause
- protocol
- quantitative trait loci (QTL) studies
- RD
- Régulation
- reproductive performance
- risk genes
- RLR
- RNA quality control
- RP1
- selection
- Single nucleotide polymorphism (SNP)
- Ski complex
- SKI2W
- SKIV2L
- SNP
- STK19
- SVA
- swine leukocyte antigen
- synaptic covering
- T-cell receptor
- T1DGC
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
- trichohepatoenteric syndrome
- type 1 diabetes (T1D)
- viral peptides
Links
DOI: 10.3390/books978-3-03928-073-5Editions
