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Natural Products and Neuroprotection

Natural Products and Neuroprotection

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Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.

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Keywords

  • 5-(3,5-dihydroxyphenyl)-γ-valerolactone
  • algae
  • Alzheimer’s disease
  • animal studies
  • antioxidant
  • ascaroside pheromone
  • auraptene
  • Autophagy
  • B-cell lymphoma 2
  • Beneficence
  • bioactive compound
  • bioavailability
  • Biology, Life Sciences
  • blood–brain barrier
  • C. elegans
  • Calcium
  • catechin
  • Cell Death
  • Centella asiatica
  • chaperones
  • Chionanthus retusus
  • Clinical Trial
  • Cognition
  • cognitive dysfunction
  • curcumin
  • Cyclic AMP
  • dauer
  • Depression
  • dopamine neuron
  • Dynamics
  • epigallocatechin gallate
  • Ethics
  • flavonoid
  • flower
  • free radicals
  • glycogen synthase kinase 3
  • green tea
  • heme oxygenase
  • Hippocampus
  • HO-1
  • hormesis
  • human studies
  • In vitro studies
  • Inflammation
  • Learning
  • Lippia citriodora
  • Mathematics & science
  • medical liability
  • Memory
  • microbiota
  • Mitochondria
  • Mitochondrial dysfunction
  • mitophagy
  • Multiple Sclerosis
  • n/a
  • natural compound
  • natural compounds
  • natural extract
  • Natural Products
  • neurodegeneration
  • neurodegenerative disease
  • Neurodegenerative Diseases
  • neuroinflammation
  • neuronal signaling
  • Neuroprotection
  • NO
  • nonmaleficence
  • Nutraceuticals
  • oxidative injury
  • Oxidative Stress
  • parkinson’s disease
  • Parkinson’s disease (PD)
  • patients’ autonomy
  • protein aggregation
  • protein poshophatase 2
  • proteostasis
  • Reference, information & interdisciplinary subjects
  • relaxation
  • Research & information: general
  • safety profile
  • seaweeds
  • Sexual Behavior
  • stress response
  • survival signals
  • symptom
  • synapse loss
  • tau protein
  • terpenes, rotenone
  • thymol
  • type 2 diabetes
  • ubiquitin-proteasome
  • ubiquitin‒proteasome system (UPS)
  • Unfolded Protein Response
  • vascular damage
  • VEE
  • Vitamin D
  • Vs
  • β-amyloid peptide

Links

DOI: 10.3390/books978-3-03936-217-2

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