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Multimodal Therapy of Upper Gastrointestinal Malignancies
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Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published.
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Keywords
- adjuvant therapy
- Barrett’s esophagus
- cancer dormancy
- chemo-radiotherapy
- clinical pathways
- Complications
- conversion surgery
- definitive chemoradiotherapy
- early adenocarcinoma of esophagus
- endoscopic mucosal resection
- endoscopic submucosal dissection
- esophageal anastomosis
- esophageal cancer
- esophageal squamous cell carcinoma
- esophagectomy
- failure to rescue
- gastrectomy
- gastric cancer
- gastric surgery
- gastric/gastroesophageal cancer
- gastro-esophageal reflux disease
- gastrointestinal stromal tumor
- gastrointestinal tract
- genetic diagnosis
- Genetics
- GIST
- imatinib
- Immunotherapy
- induction chemotherapy
- Lauren histotype
- lymph node ratio
- MALT lymphoma
- medicine
- Medicine: General Issues
- minimally invasive surgery
- Mortality
- mucosal resection
- multidisciplinary
- multimodal treatment
- n/a
- neoadjuvant chemoradiotherapy
- neoadjuvant chemotherapy
- neoadjuvant therapy
- neoadjuvant treatment
- neuroendocrine tumor
- nuclear receptor NR2F1
- nutritional status
- oncological gastrectomy
- organ preservation
- outcome
- outcomes
- overall survival
- perioperative chemotherapy
- Public health & preventive medicine
- quality of care
- radiosensitivity
- relapse-free survival
- Sarcopenia
- skeletal muscle index
- squamous cell esophageal cancer
- Standardization
- Stomach
- submucosal dissection
- Survival
Links
DOI: 10.3390/books978-3-0365-0921-1Editions