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Coumarin and Its Derivatives
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Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.
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Keywords
- 3-aroylcoumarines
- 4-hydroxy-7-methoxycoumarin
- 4-hydroxycoumarin
- 6’-(4-biphenyl)-β-iso-cinchonine
- acenocoumarol
- adenosine receptors
- analytical methods
- anti-HIV
- Antibacterial activity
- anticancer activity
- anticoagulation
- antiplatelet activity
- Apoptosis
- Autophagy
- benzopyrones
- benzyl 2,3-butadienoate
- binding affinity
- Bioactivity
- Biological applications
- Biology, Life Sciences
- biosynthesis
- biotransformation
- calanolide A
- calanolides
- Calophyllaceae
- Calophyllum
- chalcocoumarin
- chalcone
- chalepensin
- chalepin
- charge transfer
- cholinesterase inhibition
- cholinesterases
- Chromobacterium violaceum
- Complementary Therapies
- constitutive androstane receptor
- coumarin
- coumarin dyes
- coumarin3-carboxamides
- coumarins
- COX
- Crohn’s disease
- curcumin
- curcumin–coumarin hybrids
- dihydrocoumarin-fused dihydropyranones
- direct laser write
- docking
- docking simulation
- Drug Discovery
- dye-sensitized solar cells
- electrophilic compounds
- Escherichia coli
- esculetin
- esculin
- ethynylaryl
- ferulenol
- five-membered aromatic heterocycles
- fluorescent probes
- free radical polymerization
- furan
- Glutathione
- glycyrol
- Glycyrrhiza uralensis
- human monoamine oxidases
- hydroxyl-modified coumarin
- Imidazole
- immunoproteasome
- impedance aggregometry
- in silico studies
- in silico tools
- Inflammation
- inflammatory bowel disease
- intestinal inflammation
- isocoumarin
- kinetics
- led
- liquiritigenin
- macrophage
- MAO-B
- MAPK
- Mathematics & science
- mechanical valve
- model plant
- Molecular Dynamics
- monoamine oxidase inhibition
- n/a
- natural genetic variation
- Natural Products
- Neurodegenerative Diseases
- Neuroprotection
- NF-κB
- non-nucleoside reverse transcriptase inhibitors (NNRTIs)
- non-peptidic
- osthole
- oxazole
- Oxidative Stress
- photocomposites
- photophysical
- plant-derived molecules
- Polyphenols
- pseudocalanolides
- psoralen core
- pyranocoumarins
- Pyrazole
- pyrrole
- QS inhibitors
- Quorum Sensing
- Reference, information & interdisciplinary subjects
- Research & information: general
- reverse transcriptase
- Ruta chalepensis
- Rutaceae
- scavenging activity
- scoparone
- selenophen
- simple coumarins
- sorafenib
- structural annotation
- thermal and structural characterization
- thiadiazole
- thiazole
- thieno [3,2-b] thiophene
- thiophene
- time in therapeutic range
- triazole
- ulcerative colitis
- umbelliferone
- warfarin
- warhead scan
- Yin Chen Hao
Links
DOI: 10.3390/books978-3-0365-2774-1Editions