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PPARs as Key Mediators of Metabolic and Inflammatory Regulation
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Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotypes, α, β/δ, and γ, which modulate metabolic and inflammatory pathways, making them key for the control of cellular, organ, and systemic processes. PPAR activity is governed by fatty acids and fatty acid derivatives, and by drugs used in clinics (glitazones and fibrates). The study of PPAR action, also modulated by post-translational modifications, has enabled extraordinary advances in the understanding of the multifaceted roles of these receptors in metabolism, energy homeostasis, and inflammation both in health and disease. This Special Issue of IJMS includes a broad range of basic and translational article, both original research and reviews, focused on the latest developments in the regulation of metabolic and/or inflammatory processes by PPARs in all organs and the microbiomes of different vertebrate species.
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Keywords
- Adipose Tissue
- AMPK
- Amygdala
- atopic dermatitis
- bezafibrate
- Biochemistry
- Biology, Life Sciences
- Brain
- browning
- Cancer
- common carotid artery occlusion
- coregulator
- corticotropin releasing hormone
- coumarin
- Crystal structure
- Cytomegalovirus
- dairy animals
- Depression
- diabetes
- DNA Methylation
- docking
- doping control
- dual/pan agonist
- electroretinography
- ELISA
- energy homeostasis
- Exercise
- fatty acid oxidation
- Fatty acids
- fenofibrate
- fenofibric acid
- fibroblast growth factor 21
- fluorescent ligand
- GDF15
- gene transcription
- Glucose
- GSK3787
- GW0742
- hepatic damage
- hepatic sex-biased gene expression
- histone modification
- HIV
- Immunity
- immunohistochemistry
- Infection
- Inflammation
- Insulin Resistance
- kidney fibrosis
- ligand
- lipid droplets
- Lipid Metabolism
- lipidomics
- lipopolysaccharide (LPS)
- liver damage
- Lung
- M. leprae
- M. tuberculosis
- Mathematics & science
- Metabolic alterations
- metabolic reprograming
- metabolic syndrome
- Microglia
- Micronutrients
- miRNA
- molecular docking
- mycobacteria
- n/a
- Neural Stem Cells
- Neurogenesis
- neuroinflammation
- Neuropathology
- nitric oxide synthase
- non-alcoholic fatty liver disease (NAFLD)
- non-alcoholic steatohepatitis (NASH)
- nonalcoholic fatty liver disease (NAFLD)
- norepinephrine
- nuclear factors
- nuclear receptor
- nuclear receptors
- Nucleus Accumbens
- Nutrigenomics
- Obesity
- oleoylethanolamide
- P2Y2 receptor
- palmitoylethanolamide
- pattern-recognition receptors
- pemafibrate
- peroxisome
- peroxisome proliferator-activated receptor
- peroxisome proliferator-activated receptor alpha
- peroxisome proliferator-activated receptor gamma (PPARγ)
- peroxisome proliferator-activated receptors (PPAR)
- peroxisome-proliferator-activated receptor
- Phagocytosis
- pharmacological targets
- PPAR
- PPAR gamma
- PPARg
- PPARs
- PPARα
- PPARα knockout
- PPARβ/δ
- PPARγ
- PPARγ ligand
- PPRE
- proliferation
- psoriasis
- pulmonary arterial hypertension
- pulmonary artery
- quercetin
- real-time PCR
- Reference, information & interdisciplinary subjects
- regulatory T cells
- Research & information: general
- resveratrol
- retinal ischemia
- screening
- sex dimorphism
- signaling pathway
- skeletal muscle
- subgenual prefrontal cortex
- substrate metabolism
- TGFβ
- toll-like receptor 4
- type 2 diabetes mellitus
- vascular injury
- X-ray crystallography
- Zika
- β-oxidation
Links
DOI: 10.3390/books978-3-0365-4191-4Editions