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Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach
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Although DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repair enzymes could help to overcome this resistance. The reviews and research articles included in this collection describe the molecular mechanisms of action of some important enzymes of the DNA repair system, as well as some new inhibitors of such enzymes and the pharmacological properties of these inhibitors. This reprint clearly demonstrates the importance of the inhibition of DNA repair enzymes to fight various diseases, especially cancer.
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Keywords
- 7-methylguanine
- Akt signaling
- APE1
- Apoptosis
- arsenic trioxide
- base excision repair
- berberine
- Biology, Life Sciences
- Cancer
- cancer therapy
- CDKN2A
- cell cycle checkpoint
- chemical space
- chemotherapy
- combination therapy
- coumarin
- CSB
- cyclobutane–pyrimidine dimer (CPD) photolesion
- DNA Damage
- DNA glycosylases
- DNA Repair
- DNA repair enzyme
- DNA repair enzymes
- DNA repair inhibitors
- docking
- drug targets
- ERCC1-XPF
- fluorescence anisotropy
- fluorescence techniques
- fused in sarcoma
- gastrointestinal stromal tumors (GIST)
- HEK293 knockout cell line
- homology-mediated DNA repair
- inhibiting activity
- inhibitor
- KU-0060648
- KU55933
- Mathematics & science
- Molecular Dynamics
- molecular modeling
- morpholino nucleosides
- multifunctional disordered protein
- n/a
- NAD+ analogs
- neoflavone
- Non-Small Cell Lung Cancer
- nucleosome
- nucleotide excision repair (NER)
- olaparib
- PARP
- PARP-1
- PARP-1 inhibitors
- PARP1
- poly (ADP-ribose) polymerase inhibitor
- poly(ADP-ribose)
- poly(ADP-ribose) polymerase
- poly(ADP-ribose) polymerase 1
- poly(ADP-ribosylation)
- Polyphenols
- protein phase separation
- protein–protein interactions
- Rad51 recombinase
- Radiotherapy
- Reference, information & interdisciplinary subjects
- Research & information: general
- Resistance
- resveratrol
- SAR
- SCR7 pyrazine
- sensitization
- soft tissue sarcomas (STS)
- spFRET microscopy
- spironolactone
- synergism
- synergy
- synthetic lethality
- Tdp1 inhibitor
- TDP2
- tetrahydroberberine
- thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
- thioether
- topoisomerase 1 inhibitors
- topotecan
- Trapping
- tumor
- tyrosyl-DNA phosphodiesterase 1
- usnic acid
- UVB mutagenesis
- UVB radiation
- veliparib
- Vero cells
- XPA
Links
DOI: 10.3390/books978-3-0365-7880-4Editions