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Antitumoral Properties of Natural Products
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Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment.
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Keywords
- 13-ethylberberine
- Akt
- anthraquinones
- anti-cancer
- anti-cancer activity
- anti-cancer agents
- anti-tumor activity
- anticancer
- antioxidant activities
- Antioxidants
- antioxidation
- antiproliferation agents
- antiproliferative
- antiproliferative activity
- antitumoral activity
- antrodin C
- Apoptosis
- AR
- Artemisia absinthium
- ASE
- Aspergillus fumigatus
- ATM-Chk2
- autophagic flux inhibition
- Autophagy
- bee venom
- betulinic acid
- Biology, Life Sciences
- Brazilian Cerrado biome
- Cancer
- cancer stem cells
- capsazepine
- carrageenan
- Catalpa speciosa
- Celastraceae
- cell cycle arrest
- cell proliferation
- Cell signaling
- cephalotaxine
- cervical cancer
- Cheiloclinium cognatum
- chemotherapeutic adjuvant
- chemotherapy
- chiral resolution
- CIP2A
- CLE-10
- CLEFMA
- Colocasia esculenta
- colorectal cancer cells
- Copper
- Cordyceps sinensis
- coronarin D
- CrataBL
- cryptolepine
- Cucurbitacin B
- cytotoxic activity
- Cytotoxicity
- Dendrobium officinale
- diallyl disulfide
- dicentrine
- DLD-1 cells
- doxorubicin
- drug resistance
- ECD calculation
- EGFR
- Endoplasmic Reticulum Stress
- entrapment efficiency
- Euphorbia tirucalli
- FAK/S6K1
- Flavonoids
- folk medicine
- food bioactive
- FOXO1
- Fruit
- Ganoderma tsugae
- gastric cancer
- gastric cancer cells
- gefitinib-resistant NSCLC
- Gene expression
- Glioblastoma
- glioblastoma multiforme
- Glioma
- glucose uptake
- glycosyltransferase
- grape leaves
- human neuroblastoma cells
- IL-6/JAK2/STAT3
- Inflammation
- Inflammatory diseases
- ingenol
- Invasion
- isochromanes
- isocryptolepine
- JNK
- lactoferrin hydrolysate
- LC3
- lichen
- Licochalcone A
- lipogenesis
- lung adenocarcinoma
- lysosomal degradation
- lysosomal membrane permeabilization
- Magnolia acuminata
- Manganese
- MAPK
- Mathematics & science
- MCF-7 cells
- MDA-MB-231
- Melanoma
- melittin
- mesenchymal stem cells
- metabolic stability
- metastasis
- microenvironment
- migration
- mitochondrial membrane potential
- mitochondrial ROS
- mitochondrial-dependent pathway
- molecular mechanism
- mTOR
- multiple myeloma
- n/a
- naringenin
- natural compounds
- natural product alkaloids
- Natural Products
- natural yellow Monascus pigments
- NCI-60 cancer cell line
- necrotic
- neferine
- neocryptolepine
- NF-κB
- no-toxicity
- Nutraceuticals
- oncogene
- Osteosarcoma
- p38
- patuletin
- phenols
- phloretin
- Phytochemicals
- PI3K/AKT/mTOR
- PI3K/Akt/mTOR pathway
- plant lectin
- plant-derived foods
- plantation mode
- Plenckia populnea
- porphyran
- preclinical tests
- pristimerin
- pro-apoptotic effects
- proanthocyanins
- prostate cancer
- protease inhibitor
- Protein Kinase C
- protein synthesis inhibition
- Pulsatilla saponin D
- Quality control
- quercetagetin
- quercetin
- Reference, information & interdisciplinary subjects
- Research & information: general
- ROS
- RT-R breast cancer cells
- Salacia crassifolia
- Salacia elliptica
- SB365
- seaweed
- secondary metabolites
- semi-synthetic derivative
- SREBP-1
- stable nanocapsules
- stemness potential
- structure activity relationships
- structure elucidation
- tarin
- Taxus cuspidata
- temozolomide
- TNF-α
- TP
- traditional preparation
- transcriptional regulation
- triterpenoids
- TRPV1
- tumidulin
- ursolic acid
- vegetable
- water-soluble
- zerumbone
- Zeylenone
Links
DOI: 10.3390/books978-3-03943-115-1Editions